|
KMID : 0848120140390010001
|
|
International Journal of Oral Biology
2014 Volume.39 No. 1 p.1 ~ p.7
|
|
|
A Neuromedin B Receptor Blockade Inhibits the Growth of Human Oral Cancer Cells
|
|
Park Hyun-Joo
Jeon Jae-Hoon
Kim Mi-Kyoung
Ryu Mi-Heon
Kim Yong-Deok
Bae Soo-Kyung
Bae Moon-Kyoung
|
|
|
Abstract
|
|
|
|
Neuromedin B (NMB) acts as a growth factor or a morphogen and plays a role in cancer progression. Indeed, the NMB receptor (NMB-R) is overexpressed in different types of tumors. In our current study, we investigated the involvement of NMB-R in the proliferation of oral cancer cells. Human oral squamous cell carcinoma (SCC) and human oral cancer cells, SCC-25 cells were found to be NMB-R-positive. The NMB-R antagonist PD168368 inhibited the proliferation of SCC-25 cells and reduced their colony formation capacity. We also found that PD168368 induced the cell cycle arrest and apoptosis of SCC-25 cells in a dose-/time-dependent manner. Overall, this antitumor activity of PD168368 in human oral cancer cells suggests that NMB-R is a potential target for the future prevention and treatment of human cancers.
|
|
|
KEYWORD
|
|
|
human oral cancer cells , neuromedin B receptor , PD168368 , apoptosis , cell cycle arrest.
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|